DUBAI (Reuters) — Iranian Supreme leader Ayatollah Ali Khamenei said on Thursday European countries were unlikely to help Iran against U.S. sanctions, and Tehran “should give up all hope” in that regard, according to his official website.

Britain, France and Germany, parties to a 2015 nuclear deal with Iran, have tried to set up a trade mechanism to barter humanitarian and food goods with Iran after the United States withdrew from the deal last year and re-imposed sanctions. However, the mechanism is still not operational.

Iran has repeatedly said it will ramp up its nuclear activities unless the European countries do more to protect its economy from the impact of the U.S. sanctions.

“Despite their promises, the Europeans have practically adhered to America’s sanctions and have not taken any action and are unlikely to do anything for the Islamic Republic in the future. So one should give up all hope on Europeans”, Khamenei was quoted as saying.

“There should be no trust in countries that have held the banner of hostility to (Iran’s) Islamic system, led by the United States and some European countries, because they are openly hostile to the Iranian people,” Khamenei said.

“The road to interaction and negotiations is open to all countries other than America and the Zionist regime [Israel]”, Khamenei told members of a powerful clerical body.