The deterioration of bilateral relations between Pakistan and the U.S. represents at once potential peril for the region and an opportunity for the U.S. and the Central Asian states. Although the U.S./Pakistan bilateral relationship has been in decline for some time — the result of a combination of conflicting military objectives, a lack of trust, and perceived Pakistani corruption — the dramatic recent disintegration opens the door for a rebalancing of relationships between the U.S. and some of the regional states. The ability of the U.S. to influence the future course of events will in turn be influenced by the role China and Russia in the evolving landscape.